Discovery of dipeptidyl peptidase-4 inhibitor specific biomarker in non-alcoholic fatty liver disease mouse models using modified basket trial

• Published in: Clinical and molecular hepatology Vol. 28; no. 3; pp. 497 - 509
• Main Authors: Ju Hee Oh, Dae Won Jun, Hye Young Kim, Seung Min Lee, Eileen L. Yoon, Jungwook Hwang, Jung Hwan Park, Hanbi Lee, Wankyu Kim, Hyunsung Kim
• Format: Journal Article
• Language: Korean
• Published: 대한간학회 01.07.2022
• Subjects: Biomarker; Biopsy; Dipeptidyl peptidase 4 inhibitor; Insulin-like growth factor binding protein 1; Nonalcoholic fatty liver disease

Background/Aims: We aimed to define an optimal target population and drug-specific biomarkers that may predict dipeptidyl peptidase (DPP)-4 inhibitor responses in non-alcoholic fatty liver disease (NAFLD). Methods: An exploration study (study I) was performed using three different NAFLD models (bask...