Induction of a Hardening Phenomenon and Quantitative Changes of Ceramides in Stratum Corneum
Background: Hardening phenomenon of human skin after repeated exposure to the irritants is well-known, but the precise mechanism remains elusive. Objective: To modify the previous experimental model of hardening phenomenon by repeated applications of two different concentrations of sodium lauryl sul...
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Published in | Annals of dermatology Vol. 26; no. 1; pp. 35 - 42 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | Korean |
Published |
대한피부과학회
28.02.2014
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Abstract | Background: Hardening phenomenon of human skin after repeated exposure to the irritants is well-known, but the precise mechanism remains elusive. Objective: To modify the previous experimental model of hardening phenomenon by repeated applications of two different concentrations of sodium lauryl sulfate (SLS) solutions to Korean healthy volunteers and to investigate the quantitative changes of ceramides in stratum corneum before and after chronic repeated irritation. Methods: Eight hundred microliters of distilled water containing 0.1% and 2% SLS was applied for 10 minutes on the forearm of 41 healthy volunteers for 3 weeks. After an intervening 3-week rest, 24-hour patch tests with 1% SLS were conducted on previously irritated sites. Transepidermal water loss (TEWL), erythema index and quantity of ceramide were measured in the stratum corneum before and after irritation. Results: TEWL values on the sites preirritated with 2% SLS were lower than those with 0.1% SLS. Hardening phenomenon occurred in 24 volunteers at day 44. The changes in ceramide levels were not significantly higher in the hardened skin than in the non-hardened skin. Conclusion: Repetitive stimulation with a higher concentration of SLS can more easily trigger skin hardening. (Ann Dermatol 26(1) 35∼42, 2014) |
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AbstractList | Background: Hardening phenomenon of human skin after repeated exposure to the irritants is well-known, but the precise mechanism remains elusive. Objective: To modify the previous experimental model of hardening phenomenon by repeated applications of two different concentrations of sodium lauryl sulfate (SLS) solutions to Korean healthy volunteers and to investigate the quantitative changes of ceramides in stratum corneum before and after chronic repeated irritation. Methods: Eight hundred microliters of distilled water containing 0.1% and 2% SLS was applied for 10 minutes on the forearm of 41 healthy volunteers for 3 weeks. After an intervening 3-week rest, 24-hour patch tests with 1% SLS were conducted on previously irritated sites. Transepidermal water loss (TEWL), erythema index and quantity of ceramide were measured in the stratum corneum before and after irritation. Results: TEWL values on the sites preirritated with 2% SLS were lower than those with 0.1% SLS. Hardening phenomenon occurred in 24 volunteers at day 44. The changes in ceramide levels were not significantly higher in the hardened skin than in the non-hardened skin. Conclusion: Repetitive stimulation with a higher concentration of SLS can more easily trigger skin hardening. (Ann Dermatol 26(1) 35∼42, 2014) |
Author | Jin Hye Kim Sook Young Park Chun Wook Park Soo Ick Cho Hye One Kim Kyeong Il Kim Hee Jin Cho Cheol Heon Lee |
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Snippet | Background: Hardening phenomenon of human skin after repeated exposure to the irritants is well-known, but the precise mechanism remains elusive. Objective: To... |
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SubjectTerms | Ceramides Hardening phenomenon Irritation contact dermatitis |
Title | Induction of a Hardening Phenomenon and Quantitative Changes of Ceramides in Stratum Corneum |
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