Reviews : A Systematic Review of Oxidative Stress and Safety of Antioxidants in Diabetes: Focus on Islets and Their Defense

• Published in: Diabetes & metabolism journal Vol. 37; no. 2; pp. 106 - 112
• Main Authors: Keun Gyu Park, Udayakumar Karunakaran
• Format: Journal Article
• Language: Korean
• Published: 대한당뇨병학회 30.04.2013
• Subjects: Glucose stimulated insulin secretion; Nitric oxide; Reactive nitrogen species; Reactive oxygen species; Superoxide dismutase

A growing body of evidence suggests that hyperglycemia-induced oxidative stress plays an important role in diabetic complications, especially β-cell dysfunction and failure. Under physiological conditions, reactive oxygen species serve as second messengers that facilitate signal transduction and gen...