Treatment and Prevention of Rat Glioblastma by Immunogenic C6 Cells Expressing Antisense Insulin-Like Growth Factor I RNA

• Published in: Science (American Association for the Advancement of Science) Vol. 259; no. 5091; pp. 94 - 97
• Main Authors: Trojan, Jerzy, Johnson, Thomas R., Rudin, Susan D., Ilan, Judith, Tykocinski, Mark L., Ilan, Joseph
• Format: Journal Article
• Language: English
• Published: American Society for the Advancement of Science 01.01.1993
• Subjects: Antibodies; Cell lines; Cellular immunity; Glioma; Lymphocytes; Neuroblastoma; Neurons; Somatic cells; Tumor cell line; Tumors

Rat C6 glioma cells express insulin-like growth factor I (IGF-I) and form rapidly growing tumors in syngeneic animals. When transfected with an episome-based vector encoding antisense IGF-I complementary DNA, these cells lost tumorigenicity. Subcutaneous injection of IGF-I antisense-transfected C6 c...