Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA41g

Antigen-specific T cell activation depends on T cell receptor-ligand interaction and costimulatory signals generated when accessory molecules bind to their ligands, such as CD28 to the B7 (also called BB1) molecule. A soluble fusion protein of human CTLA-4 (a protein homologous to CD28) and the immu...

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Published inScience (American Association for the Advancement of Science) Vol. 257; no. 5071; pp. 789 - 792
Main Authors Lenschow, Deborah J., Zeng, Yijun, Thistlethwaite, J. Richard, Montag, Anthony, Brady, William, Gibson, Marylou G., Linsley, Peter S., Bluestone, Jeffrey A.
Format Journal Article
LanguageEnglish
Published American Society for the Advancement of Science 07.08.1992
Subjects
Graft rejection
Graft survival
Humans
Islets of Langerhans
Kidneys
Mice
T lymphocytes
Tissue grafting
Tissue transplantation
Transplantation
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Summary:Antigen-specific T cell activation depends on T cell receptor-ligand interaction and costimulatory signals generated when accessory molecules bind to their ligands, such as CD28 to the B7 (also called BB1) molecule. A soluble fusion protein of human CTLA-4 (a protein homologous to CD28) and the immunoglobulin (Ig) G1 Fc region (CTLA4Ig) binds to human and murine B7 with high avidity and blocks T cell activation in vitro. CTLA4Ig therapy blocked human pancreatic islet rejection in mice by directly affecting T cell recognition of B7$^+$ antigen-presenting cells. In addition, CTLA4Ig induced long-term, donor-specific tolerance, which may have applications to human organ transplantation.
ISSN:0036-8075
1095-9203