Herpes Simples Virus Immediate Early Infected-Cell Polypeptide 4 Binds to DNA and Promotes Transcription

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 83; no. 11; pp. 4016 - 4020
• Main Authors: Beard, Peter, Faber, Steve, Wilcox, Kent W., Pizer, Lewis I.
• Format: Journal Article
• Language: English
• Published: National Academy of Sciences of the United States of America 01.06.1986
• Subjects: Antibodies; DNA; Gels; Genes; Messenger RNA; Plasmids; RNA; Simplexvirus; Transcriptional regulatory elements; Viral genes

In herpes simplex virus (HSV)-infected cells, there is a sequential expression of viral genes. In vivo experiments have implicated the Mr 175,000 immediate early protein ICP4 (infected-cell polypeptide 4) in the regulation of viral RNA synthesis, but the mechanism whereby ICP4 regulates transcriptio...