Redeploying ß-Lactam Antibiotics as a Novel Antivirulence Strategy for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections

• Published in: The Journal of infectious diseases Vol. 215; no. 1; pp. 80 - 87
• Main Authors: Waters, Elaine M., Rudkin, Justine K., Coughlan, Simone, Clair, Geremy C., Adkins, Joshua N., Gore, Suzanna, Xia, Guoqing, Black, Nikki S., Downing, Tim, O'Neill, Eoghan, Kadioglu, Aras, O'Gara, James P.
• Format: Journal Article
• Language: English
• Published: Oxford University Press 01.01.2017
• Subjects: BACTERIA

Innovative approaches to the use of existing antibiotics is an important strategy in efforts to address the escalating antimicrobial resistance crisis. We report a new approach to the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections by demonstrating that oxacillin can be us...