Breathless on bortezomib

The authors describe a case of episodic acute pneumonitis occurring after repeated doses of bortezomib, a drug being used increasingly to treat multiple myeloma. The delay in presentation each time with fever, dyspnoea, hypoxia and interstitial radiological changes contributed to under-recognition o...

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Published inBMJ Case Reports Vol. 2011
Main Authors O’Riordan, Devaki, Houghton, John, Chisholm, Roger, O’Driscoll, B Ronan
Format Report
LanguageEnglish
Published BMJ Publishing Group Ltd 2011
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Abstract The authors describe a case of episodic acute pneumonitis occurring after repeated doses of bortezomib, a drug being used increasingly to treat multiple myeloma. The delay in presentation each time with fever, dyspnoea, hypoxia and interstitial radiological changes contributed to under-recognition of this complication, which has so far been described in only a handful of patients, but the pattern seen may offer clues to pathogenesis and potential treatments. This case highlights the need for both physicians and patients consenting to bortezomib treatment to be more aware of this potentially fatal adverse effect.
AbstractList The authors describe a case of episodic acute pneumonitis occurring after repeated doses of bortezomib, a drug being used increasingly to treat multiple myeloma. The delay in presentation each time with fever, dyspnoea, hypoxia and interstitial radiological changes contributed to under-recognition of this complication, which has so far been described in only a handful of patients, but the pattern seen may offer clues to pathogenesis and potential treatments. This case highlights the need for both physicians and patients consenting to bortezomib treatment to be more aware of this potentially fatal adverse effect.
Author O’Driscoll, B Ronan
O’Riordan, Devaki
Chisholm, Roger
Houghton, John
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  fullname: O’Driscoll, B Ronan
  organization: Respiratory Medicine Department, MAHSC at Salford Royal NHS Foundation Trust, Manchester, UK
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