An unusual cause of severe persistent neutropenia in a child with nephrotic syndrome

A 5-year-old boy presented with neutropenia 9 weeks following the administration of rituximab for management of his steroid-dependent nephrotic syndrome. Extensive investigations failed to identify any underlying cause. In keeping with adult reports, rituximab was thought to be the likely cause for...

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Bibliographic Details
Published inBMJ Case Reports Vol. 2013
Main Authors Kshirsagar, Archana A, Reid, Christopher J D, Alamelu, Jayanthi, Sinha, Manish D
Format Report
LanguageEnglish
Published BMJ Publishing Group Ltd 2013
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Summary:A 5-year-old boy presented with neutropenia 9 weeks following the administration of rituximab for management of his steroid-dependent nephrotic syndrome. Extensive investigations failed to identify any underlying cause. In keeping with adult reports, rituximab was thought to be the likely cause for this ‘late-onset’ neutropenia (LOP). He was treated successfully with granulocyte-colony-stimulating factor. Patients treated with rituximab need to be carefully monitored for LOP.
Bibliography:local:casereports;2013/jan29_1/bcr2012007958
ArticleID:bcr-2012-007958
ark:/67375/NVC-526MPMDP-V
href:casereports-2013-bcr-2012-007958.pdf
istex:D2CD01CAD7B44F6CF0195F3096071BA18120D98E
ISSN:1757-790X
DOI:10.1136/bcr-2012-007958