Pituitary carcinoma recurrent to the lumbar intradural extramedullary space: Case report
Context Pituitary tumors are rare, and pituitary carcinomas are rarer still. Prognosis is poor, with less than 50% of patients surviving past 1 year after diagnosis. In this case of spinal metastasis from an adrenocorticotropic hormone-secreting pituitary carcinoma, the intradural extramedullary met...
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Published in | The Journal of Spinal Cord Medicine Vol. 35; no. 2; pp. 118 - 121 |
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Main Authors | , , , |
Format | Report |
Language | English |
Published |
Taylor & Francis
01.03.2012
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Subjects | |
Online Access | Get full text |
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Abstract | Context
Pituitary tumors are rare, and pituitary carcinomas are rarer still. Prognosis is poor, with less than 50% of patients surviving past 1 year after diagnosis. In this case of spinal metastasis from an adrenocorticotropic hormone-secreting pituitary carcinoma, the intradural extramedullary metastases recurred in the same lumbar area 6 years apart.
Findings
Fourteen years prior to presentation in our clinic, a 48-year-old woman was diagnosed with pituitary adenoma which was treated with resection followed by radiation. Eight years later, an intradural extramedullary spinal drop metastasis at L2-L3 was again treated with resection and radiation. Three years later, magnetic resonance imaging (MRI) revealed a mass encasing the right carotid artery, which was treated for 1 year with chemotherapy using temozolomide (Temodar). Three years later, MRI showed intradural extramedullary metastases at the L3-L4 intervertebral disc space and behind the L3 vertebral body; treatment was again resection followed by radiation. Back pain and weakness resolved after surgery and her neurological examination returned to baseline. There was no evidence of recurrence 1 year after surgery.
Conclusion/clinical relevance
In this unusual case, this pituitary carcinoma metastasized twice in 6 years to virtually the same intradural extramedullary lumbar region. Surgical resection of these masses aided in relieving neurological symptoms and prolonging life. |
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AbstractList | Context
Pituitary tumors are rare, and pituitary carcinomas are rarer still. Prognosis is poor, with less than 50% of patients surviving past 1 year after diagnosis. In this case of spinal metastasis from an adrenocorticotropic hormone-secreting pituitary carcinoma, the intradural extramedullary metastases recurred in the same lumbar area 6 years apart.
Findings
Fourteen years prior to presentation in our clinic, a 48-year-old woman was diagnosed with pituitary adenoma which was treated with resection followed by radiation. Eight years later, an intradural extramedullary spinal drop metastasis at L2-L3 was again treated with resection and radiation. Three years later, magnetic resonance imaging (MRI) revealed a mass encasing the right carotid artery, which was treated for 1 year with chemotherapy using temozolomide (Temodar). Three years later, MRI showed intradural extramedullary metastases at the L3-L4 intervertebral disc space and behind the L3 vertebral body; treatment was again resection followed by radiation. Back pain and weakness resolved after surgery and her neurological examination returned to baseline. There was no evidence of recurrence 1 year after surgery.
Conclusion/clinical relevance
In this unusual case, this pituitary carcinoma metastasized twice in 6 years to virtually the same intradural extramedullary lumbar region. Surgical resection of these masses aided in relieving neurological symptoms and prolonging life. |
Author | O'Neil, Maura F. Johnson, Philip L. Arnold, Paul M. Ratnasingam, Denesh |
Author_xml | – sequence: 1 givenname: Paul M. surname: Arnold fullname: Arnold, Paul M. email: parnold@kumc.edu organization: University of Kansas Medical Center – sequence: 2 givenname: Denesh surname: Ratnasingam fullname: Ratnasingam, Denesh organization: University of Missouri-Kansas City, School of Medicine – sequence: 3 givenname: Maura F. surname: O'Neil fullname: O'Neil, Maura F. organization: University of Kansas Medical Center – sequence: 4 givenname: Philip L. surname: Johnson fullname: Johnson, Philip L. organization: University of Kansas Medical Center |
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Copyright | The Academy of Spinal Cord Injury Professionals, Inc. 2012 2012 |
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Snippet | Context
Pituitary tumors are rare, and pituitary carcinomas are rarer still. Prognosis is poor, with less than 50% of patients surviving past 1 year after... |
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StartPage | 118 |
SubjectTerms | ACTH-secreting; Disc Intervertebral Intradural-extramedullary L2-L3; Pituitary adenoma L3-L4 Neoplasm; Spinal cord neoplasms Pituitary carcinoma; Metastases |
Title | Pituitary carcinoma recurrent to the lumbar intradural extramedullary space: Case report |
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