Combinatorial Interaction of Scorpion Toxins Lqh-2, Lqh-3, and LqhαIT with Sodium Channel Receptor Sites-3

• Published in: Molecular pharmacology Vol. 65; no. 3; p. 685
• Main Authors: Enrico Leipold, Songqing Lu, Dalia Gordon, Alfred Hansel, Stefan H. Heinemann
• Format: Journal Article
• Language: English
• Published: American Society for Pharmacology and Experimental Therapeutics 01.03.2004

Scorpion α-toxins LqhαIT, Lqh-2, and Lqh-3 are representatives of three groups of α-toxins that differ in their preference for insects and mammals. These α-insect, antimammalian, and α-like toxins bind to voltage-gated sodium channels and slow down channel inactivation. Sodium channel mutagenes...