Pharmacological Characterization of In Vivo Properties of Putative Mixed 5-HT1AAgonist/5-HT2A/2C Antagonist Anxiolytics. II. Drug Discrimination and Behavioral Observation Studies in Rats

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 282; no. 2; p. 747
• Main Authors: Mark S. Kleven, Marie-Bernadette AssiÃ, Wouter Koek
• Format: Journal Article
• Language: English
• Published: American Society for Pharmacology and Experimental Therapeutics 01.08.1997

To characterize their in vivo 5-hydroxytryptamine (5-HT) 2A antagonist properties, the ability of the putative mixed 5-HT 1A agonists/5-HT 2A/2C antagonists (N-(29(4-(2-pyrimidinyl)-1-piperazinyl)ethyl)tricyclo(3.3.1.1(3,7)) decane-1-carboxamide (WY-50,324), (2-(4-(4,4-bis(4-fluorophenyl)butyl)-1-pi...