Influence of Amifostine on the Toxicity and Pharmacokinetics of Docetaxel in Metastatic Breast Cancer Patients

• Published in: Clinical cancer research Vol. 8; no. 1; p. 95
• Main Authors: Gilles Freyer, Philippe Hennebert, Ahmad Awada, Thierry Gil, Joseph Kerger, Jean Selleslags, Christiane Brassinne, Martine Piccart, Dominique de Valeriola
• Format: Journal Article
• Language: English
• Published: American Association for Cancer Research 01.01.2002

Preclinical studies suggest that amifostine could protect against toxicities induced by taxoids. We conducted a clinical and pharmacokinetic pilot study to assess the feasibility and toxicity of the docetaxel plus amifostine combination and the absence of influence of amifostine on docetaxel pharmac...