Rapamycin Inhibits Telomerase Activity by Decreasing the hTERT mRNA Level in Endometrial Cancer Cells1

• Published in: Molecular cancer therapeutics Vol. 2; no. 8; p. 789
• Main Authors: Chunxiao Zhou, Paola A. Gehrig, Young E. Whang, John F. Boggess
• Format: Journal Article
• Language: English
• Published: American Association for Cancer Research 01.08.2003

Rapamycin exerts its biological activity by inhibiting the kinase mammalian target of rapamycin (mTOR), which regulates important cellular processes such as control of cell cycle and cell size, translation initiation, and transcription. The ability of rapamycin to inhibit cancer cell proliferation h...