Membrane Targeting and Coupling of NHE1-IntegrinαIIbβ3-NCX1 by Lipid Rafts following Integrin-Ligand Interactions Trigger Ca2+ Oscillations

• Published in: The Journal of biological chemistry Vol. 284; no. 6; p. 3855
• Main Authors: Yung-Hsiang Yi, Pei-Yun Ho, Tung-Wei Chen, Wen-Jie Lin, Vladimir Gukassyan, Tsung-Heng Tsai, Da-Wei Wang, Tien-Shen Lew, Chih-Yung Tang, Szecheng J. Lo, Tsung-Yu Chen, Fu-Jen Kao, Chi-Hung Lin
• Format: Journal Article
• Language: English
• Published: American Society for Biochemistry and Molecular Biology 06.02.2009

The cyclic calcium release and uptake during calcium oscillation are thought to result from calcium-induced calcium release (CICR); however, it is unclear, especially in nonexcitable cells, how the initial calcium mobilization that triggers CICR occurs. We report here a novel mechanism, other than c...