Activation of Cytosolic Phospholipase A2α in Resident Peritoneal Macrophages by Listeria monocytogenes Involves Listeriolysin O and TLR2

• Published in: The Journal of biological chemistry Vol. 283; no. 8; p. 4744
• Main Authors: Shahid Noor, Howard Goldfine, Dawn E. Tucker, Saritha Suram, Laurel L. Lenz, Shizuo Akira, Satoshi Uematsu, Milena Girotti, Joseph V. Bonventre, Kevin Breuel, David L. Williams, Christina C. Leslie
• Format: Journal Article
• Language: English
• Published: American Society for Biochemistry and Molecular Biology 22.02.2008

Eicosanoid production by macrophages is an early response to microbial infection that promotes acute inflammation. The intracellular pathogen Listeria monocytogenes stimulates arachidonic acid release and eicosanoid production from resident mouse peritoneal macrophages through activation of group IV...