Prion Protein Amyloid Formation under Native-like Conditions Involves Refolding of the C-terminal α-Helical Domain

• Published in: The Journal of biological chemistry Vol. 283; no. 50; p. 34704
• Main Authors: Nathan J. Cobb, Adrian C. Apetri, Witold K. Surewicz
• Format: Journal Article
• Language: English
• Published: American Society for Biochemistry and Molecular Biology 12.12.2008

Transmissible spongiform encephalopathies are associated with conformational conversion of the cellular prion protein, PrP C , into a proteinase K-resistant, amyloid-like aggregate, PrP Sc . Although the structure of PrP Sc remains enigmatic, recent studies have afforded increasingly detailed charac...