Characterization of the Interaction of Phorbol Esters with the C1 Domain of MRCK (Myotonic Dystrophy Kinase-related Cdc42 Binding Kinase) α/Î

• Published in: The Journal of biological chemistry Vol. 283; no. 16; p. 10543
• Main Authors: Sung Hee Choi, Gabriella Czifra, Noemi Kedei, Nancy E. Lewin, Jozsef Lazar, Yongmei Pu, Victor E. Marquez, Peter M. Blumberg
• Format: Journal Article
• Language: English
• Published: American Society for Biochemistry and Molecular Biology 18.04.2008

C1 domains mediate the recognition and subsequent signaling response to diacylglycerol and phorbol esters by protein kinase C (PKC) and by several other families of signal-transducing proteins such as the chimerins or RasGRP. MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase), a member of...