The Co-repressor Hairless Protects RORα Orphan Nuclear Receptor from Proteasome-mediated Degradation

• Published in: The Journal of biological chemistry Vol. 278; no. 52; p. 52511
• Main Authors: Anna N. Moraitis, Vincent Giguère
• Format: Journal Article
• Language: English
• Published: American Society for Biochemistry and Molecular Biology 26.12.2003

RORα is a constitutively active orphan nuclear receptor essential for cerebellar development and is previously shown to regulate genes involved in both myogenesis and adipogenesis. The transcriptional activity of RORα is dependent on the presence of a ubiquitous ligand and can be abolished by inte...