Induction of Direct Endosome to Endoplasmic Reticulum Transport in Chinese Hamster Ovary (CHO) Cells (LdlF) with a Temperature-sensitive Defect in ϵ-Coatomer Protein (ϵ-COP)

• Published in: The Journal of biological chemistry Vol. 278; no. 37; p. 35850
• Main Authors: Alicia Llorente, Silje U. Lauvrak, Bo van Deurs, Kirsten Sandvig
• Format: Journal Article
• Language: English
• Published: American Society for Biochemistry and Molecular Biology 12.09.2003

In the present study we demonstrate that ricin, apparently without passing through the Golgi apparatus, reaches the endoplasmic reticulum (ER) and intoxicates cells in which the Golgi apparatus has been vesiculated by depletion of ϵ-COP, a subunit of COPI. LdlF cells contain a temperature-sensitive...