Identification, Substrate Specificity, and Inhibition of theStreptococcus pneumoniae β-Ketoacyl-Acyl Carrier Protein Synthase III (FabH)

• Published in: The Journal of biological chemistry Vol. 276; no. 32; p. 30024
• Main Authors: Sanjay S. Khandekar, Daniel R. Gentry, Glenn S. Van Aller, Patrick Warren, Hong Xiang, Carol Silverman, Michael L. Doyle, Pamela A. Chambers, Alex K. Konstantinidis, Martin Brandt, Robert A. Daines, John T. Lonsdale
• Format: Journal Article
• Language: English
• Published: American Society for Biochemistry and Molecular Biology 10.08.2001

In the bacterial type II fatty acid synthase system, β-ketoacyl-acyl carrier protein (ACP) synthase III (FabH) catalyzes the condensation of acetyl-CoA with malonyl-ACP. We have identified, expressed, and characterized the Streptococcus pneumoniae homologue of Escherichia coli FabH. S. pneumoniae F...