The Pro Domain of β-Secretase Does Not Confer Strict Zymogen-like Properties but Does Assist Proper Folding of the Protease Domain

• Published in: The Journal of biological chemistry Vol. 276; no. 13; p. 10366
• Main Authors: Xiao-Ping Shi, Elizabeth Chen, Kuo-Chang Yin, Sang Na, Victor M. Garsky, Ming-Tain Lai, Yue-Ming Li, Michael Platchek, R. Bruce Register, Mohinder K. Sardana, Mei-Jy Tang, James Thiebeau, Theresa Wood, Jules A. Shafer, Stephen J. Gardell
• Format: Journal Article
• Language: English
• Published: American Society for Biochemistry and Molecular Biology 30.03.2001

β-Secretase (BACE) is a membrane-bound aspartyl protease that cleaves the amyloid precursor protein to generate the N terminus of the amyloid β peptide. BACE is expressed as a precursor protein containing Pre, Pro, protease, transmembrane, and cytosolic domains. A soluble BACE derivative (PreProBA...