The Proximal Tyrosines of the Cytoplasmic Domain of the β Chain of the Type I Interferon Receptor Are Essential for Signal Transducer and Activator of Transcription (Stat) 2 Activation

• Published in: The Journal of biological chemistry Vol. 274; no. 7; p. 4045
• Main Authors: Owen W. Nadeau, Paul Domanski, Anna Usacheva, Shahab Uddin, Leonidas C. Platanias, Paula Pitha, Regina Raz, David Levy, Beata Majchrzak, Eleanor Fish, Oscar R. Colamonici
• Format: Journal Article
• Language: English
• Published: American Society for Biochemistry and Molecular Biology 12.02.1999

The precise role of the different subunits (α/IFNAR1 and β L /IFNAR2) of the type I interferon receptor (IFN-R) in the activation of signal transducer and activator of transcription (Stat) 1, Stat2, and Stat3 has not yet been established. In this report we demonstrate that there are functionally r...