MKK6 Activates Myocardial Cell NF-κB and Inhibits Apoptosis in a p38 Mitogen-activated Protein Kinase-dependent Manner

• Published in: The Journal of biological chemistry Vol. 273; no. 14; p. 8232
• Main Authors: Dietmar Zechner, Rian Craig, Deanna S. Hanford, Patrick M. McDonough, Roger A. Sabbadini, Christopher C. Glembotski
• Format: Journal Article
• Language: English
• Published: American Society for Biochemistry and Molecular Biology 03.04.1998

In cardiac myocytes the stimulation of p38 mitogen-activated protein kinase activates a hypertrophic growth program and the induction of the cardiac-specific genes associated with this program. This study focused on determining whether these novel growth-promoting effects are accompanied by the p38-...