Role of Estrogen Receptor Gene Demethylation and DNA Methyltransferase·DNA Adduct Formation in 5-Aza-2′deoxycytidine-induced Cytotoxicity In Human Breast Cancer Cells

• Published in: The Journal of biological chemistry Vol. 272; no. 51; p. 32260
• Main Authors: Anne T. Ferguson, Paula M. Vertino, Jeffrey R. Spitzner, Stephen B. Baylin, Mark T. Muller, Nancy E. Davidson
• Format: Journal Article
• Language: English
• Published: American Society for Biochemistry and Molecular Biology 19.12.1997

The cytosine analog 5-aza-2′-deoxycytidine is a potent inhibitor of DNA methyltransferase. Its cytotoxicity has been attributed to several possible mechanisms including reexpression of growth suppressor genes and formation of covalent adducts between DNA methyltransferase and 5-aza-2′-deoxycytid...