Role of Estrogen Receptor Gene Demethylation and DNA Methyltransferase·DNA Adduct Formation in 5-Aza-2′deoxycytidine-induced Cytotoxicity In Human Breast Cancer Cells

The cytosine analog 5-aza-2′-deoxycytidine is a potent inhibitor of DNA methyltransferase. Its cytotoxicity has been attributed to several possible mechanisms including reexpression of growth suppressor genes and formation of covalent adducts between DNA methyltransferase and 5-aza-2′-deoxycytid...

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Bibliographic Details
Published inThe Journal of biological chemistry Vol. 272; no. 51; p. 32260
Main Authors Anne T. Ferguson, Paula M. Vertino, Jeffrey R. Spitzner, Stephen B. Baylin, Mark T. Muller, Nancy E. Davidson
Format Journal Article
LanguageEnglish
Published American Society for Biochemistry and Molecular Biology 19.12.1997
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