An Antibody Reactive with Domain 4 of the Platelet-derived Growth Factor β Receptor Allows BB Binding while Inhibiting Proliferation by Impairing Receptor Dimerization

• Published in: The Journal of biological chemistry Vol. 272; no. 28; p. 17400
• Main Authors: Theodore Shulman, Frederic G. Sauer, Robin M. Jackman, Chung Nan Chang, Nicholas F. Landolfi
• Format: Journal Article
• Language: English
• Published: American Society for Biochemistry and Molecular Biology 11.07.1997

A panel of murine monoclonal antibodies was generated against the extracellular domain of the human platelet-derived growth factor (PDGF) β receptor (PDGFRβ). These antibodies were assayed for both the ability to inhibit binding of PDGF BB to PDGFRβ + cells as well as the capacity to inhibit PDGF...