Suppression of Sialyl Lewis X Expression and E-selectin-mediated Cell Adhesion in Cultured Human Lymphoid Cells by Transfection of Antisense cDNA of an α1→3 Fucosyltransferase (Fuc-T VII)

• Published in: The Journal of biological chemistry Vol. 271; no. 49; p. 31556
• Main Authors: Nozomu Hiraiwa, Taeko Dohi, Naoko Kawakami-Kimura, Miki Yumen, Katsuyuki Ohmori, Michiyuki Maeda, Reiji Kannagi
• Format: Journal Article
• Language: English
• Published: American Society for Biochemistry and Molecular Biology 06.12.1996

The antisense cDNA approach was used to identify the endogenous fucosyltransferase species responsible for synthesis of the sialyl Lewis X (NeuAcα2→3 Galβ1→4[Fucα1→3]GlcNAcβ1→R) determinant in human lymphoid cells. The cultured human adult T-cell leukemia cell line, ED40515-N, expressed...