IL-27 maintains cytotoxic Ly6C+ γδ T cells that arise from immature precursors

• Published in: The EMBO journal Vol. 43; no. 14; pp. 2878 - 2907
• Main Authors: Wiesheu, Robert, Edwards, Sarah C, Hedley, Ann, Hall, Holly, Tosolini, Marie, Fares da Silva, Marcelo Gregorio Filho, Sumaria, Nital, Castenmiller, Suzanne M, Wardak, Leyma, Optaczy, Yasmin, Lynn, Amy, Hill, David G, Hayes, Alan J, Hay, Jodie, Kilbey, Anna, Shaw, Robin, Whyte, Declan, Walsh, Peter J, Michie, Alison M, Graham, Gerard J, Manoharan, Anand, Halsey, Christina, Blyth, Karen, Wolkers, Monika C, Miller, Crispin, Pennington, Daniel J, Jones, Gareth W, Fournie, Jean-Jacques, Bekiaris, Vasileios, Coffelt, Seth B
• Format: Journal Article
• Language: English
• Published: EMBO Press 30.05.2024
• Subjects: Life Sciences; γδ T Cells; Immunology; Innate Subject Categories Cancer; IL-27; Differentiation; Cancer

In mice, γδ-T lymphocytes that express the co-stimulatory molecule, CD27, are committed to the IFNγ-producing lineage during thymic development. In the periphery, these cells play a critical role in host defense and anti-tumor immunity. Unlike αβ-T cells that rely on MHC-presented peptides to drive...