Calcium channel ITPR2 and mitochondria-ER contacts promote cellular senescence and aging

• Published in: Nature communications Vol. 12; no. 1
• Main Authors: Ziegler, D. V., Vindrieux, D., Goehrig, D., Jaber, S., Collin, Guillaume, Griveau, A., Wiel, C., Bendridi, N., Djebali, S., Farfariello, V., Prevarskaya, N., Payen, Lea, Marvel, J., Aubert, S., Flaman, Jean Michel, Rieusset, J., Martin, Nadine, Bernard, David
• Format: Journal Article
• Language: English
• Published: Nature Publishing Group 2021
• Subjects: Life Sciences

Cellular senescence is induced by stresses and results in a stable proliferation arrest accompanied by a pro-inflammatory secretome. Senescent cells accumulate during aging, promoting various age-related pathologies and limiting lifespan. The endoplasmic reticulum (ER) inositol 1,4,5-trisphosphate r...