Bis(monoacylglycero)phosphate accumulation in macrophages induces intracellular cholesterol redistribution, attenuates liver-X receptor/ATP-Binding cassette transporter A1/ATP-binding cassette transporter G1 pathway, and impairs cholesterol efflux BMP and LXRs/ABCs pathway in macrophages

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 33; no. 8; pp. 1803 - 11
• Main Authors: Luquain-Costaz, Céline, Lefai, Etienne, Arnal-Levron, Maud, Markina, Daria, Sakaï, Shota, Euthine, Vanessa, Makino, Asami, Guichardant, Michel, Yamashita, Shizuya, Kobayashi, Toshihide, Lagarde, Michel, Moulin, Philippe, Delton-Vandenbroucke, Isabelle
• Format: Journal Article
• Language: English
• Published: American Heart Association 01.08.2013
• Subjects: Animals; ATP-Binding Cassette Transporters; Cell Line; Cholesterol, LDL; Endosomes; Foam Cells; Food and Nutrition; Gene Expression; Homeostasis; Life Sciences; Lipoproteins; Lipoproteins, LDL; Lysophospholipids; Macrophages; Mice; Monoglycerides; Orphan Nuclear Receptors; Plaque, Atherosclerotic; atherosclerosis; ATP-binding cassette transporters; endosomes; lipoproteins; oxysterol receptors
• ISSN: 1079-5642; 1524-4636
• DOI: 10.1161/ATVBAHA.113.301857

OBJECTIVE: Endosomal signature phospholipid bis(monoacylglycero)phosphate (BMP) has been involved in the regulation of cellular cholesterol homeostasis. Accumulation of BMP is a hallmark of lipid storage disorders and was recently reported as a noticeable feature of oxidized low-density lipoprotein-...