Reduced Reverse Cholesterol Transport Efficacy in Healthy Men with Undesirable Postprandial Triglyceride Response

• Published in: Biomolecules (Basel, Switzerland) Vol. 10; no. 5
• Main Authors: Motte, Alexandre, Gall, Julie, Salem, Joe-Elie, Dasque, Eric, Lebot, Martine, Frisdal, Eric, Galier, Sophie, Villard, Elise, Bouaziz-Amar, Elodie, Lacorte, Jean-Marc, Charbit, Beny, Le Goff, Wilfried, Lesnik, Philippe, Guerin, Maryse
• Format: Journal Article
• Language: English
• Published: MDPI 25.05.2020
• Subjects: Life Sciences; postprandial; CETP; reverse cholesterol transport; triglyceride-rich lipoprotein; high-density lipoprotein; hypertriglyceridemia; macrophage; cholesterol efflux

Elevation of nonfasting triglyceride (TG) levels above 1.8 g/L (2 mmol/L) is associated with increased risk of cardiovascular diseases. Exacerbated postprandial hypertriglyceridemia (PP–HTG) and metabolic context both modulate the overall efficacy of the reverse cholesterol transport (RCT) pathway,...