Population Pharmacokinetics of Amikacin in Patients on Veno-Arterial Extracorporeal Membrane Oxygenation

• Published in: Pharmaceutics Vol. 14; no. 2
• Main Authors: Pressiat, Claire, Kudela, Agathe, de Roux, Quentin, Khoudour, Nihel, Alessandri, Claire, Haouache, Hakim, Vodovar, Dominique, Woerther, Paul-Louis, Hutin, Alice, Ghaleh, Bijan, Hulin, Anne, Mongardon, Nicolas
• Format: Journal Article
• Language: English
• Published: MDPI 01.02.2022
• Subjects: Life Sciences; Toxicology; amikacin; pharmacokinetic/pharmacodynamic modeling; extracorporeal membrane oxygenation; Bayesian modelization; sepsis; therapeutic drug monitoring; population pharmacokinetics

Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) support leads to complex pharmacokinetic alterations, whereas adequate drug dosing is paramount for efficacy and absence of toxicity in critically ill patients. Amikacin is a major antibiotic used in nosocomial sepsis, especially for these...