Cochleate formulations of Amphotericin b designed for oral administration using a naturally occurring phospholipid

• Published in: International journal of pharmaceutics Vol. 603
• Main Authors: Lipa-Castro, Antonio, Nicolas, Valérie, Angelova, Angelina, Mekhloufi, Ghozlene, Prost, Bastien, Chéron, Monique, Faivre, Vincent, Barratt, Gillian
• Format: Journal Article
• Language: English
• Published: Elsevier 2021
• Subjects: Galenic pharmacology; Life Sciences; Pharmaceutical sciences; phosphatidylserine; Cochleates; Caco2 cells; Amphotericin B; circular dichroism; synchrotron SAXS; oral bioavailability

The purpose of this work was to formulate the poor soluble antifungal and antiparasitic agent Amphotericin B (AmB) in cost-effective lipid-based formulations suitable for oral use in developing countries, overcoming the limitations of poor water solubility, nephrotoxicity and low oral bioavailabilit...