Arsenic-Induced SUMO-Dependent Recruitment of RNF4 into PML Nuclear Bodies

In acute promyelocytic leukemia (APL), the promyelocytic leukemia (PML) protein is fused to the retinoic acid receptor alpha (RAR). Arsenic is an effective treatment for this disease as it induces SUMO-dependent ubiquitin-mediated proteasomal degradation of the PML-RAR fusion protein. Here we analyz...

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Bibliographic Details
Published inMolecular biology of the cell
Main Authors Geoffroy, Marie-Claude, Jaffray, Ellis G, Walker, Katherine J, Hay, Ronald Thomas
Format Journal Article
LanguageEnglish
Published American Society for Cell Biology 2010
Subjects
Cellular Biology
Life Sciences
Online AccessGet full text

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