A squalamine derivative, NV669, as a novel PTP1B inhibitor: in vitro and in vivo effects on pancreatic and hepatic tumor growth

• Published in: Oncotarget Vol. 10; no. 62; pp. 6651 - 6667
• Main Authors: Carmona, Sylvie, Brunel, Jean-Michel, Bonier, Renaté, Sbarra, Véronique, Robert, Stéphane, Borentain, Patrick, Lombardo, Dominique, Mas, Eric, Gerolami, René
• Format: Journal Article
• Language: English
• Published: Impact journals 19.11.2019
• Subjects: Cancer; Human health and pathology; Life Sciences; PTP1B; liver; pancreas; cancer; aminosterol

NV669 is an aminosterol derived from squalamine found to possess strong anticancer effects. The aim of this study was to investigate NV669's beneficial effects on human pancreatic and hepatic cancer models and to decipher the cellular and molecular mechanisms involved in tumor growth decrease u...