Isolation and Characterization of Poeciguamerin, a Peptide with Dual Analgesic and Anti-Thrombotic Activity from the IPoecilobdella manillensis/I Leech

• Published in: International journal of molecular sciences Vol. 24; no. 13
• Main Authors: Wang, Chaoming, Chen, Mengrou, Lu, Xiaoyu, Yang, Shuo, Yang, Min, Fang, Yaqun, Lai, Ren, Duan, Zilei
• Format: Journal Article
• Language: English
• Published: MDPI AG 01.07.2023
• Subjects: Peptides; China

When Poecilobdella manillensis attacks its prey, the prey bleeds profusely but feels little pain. We and other research teams have identified several anticoagulant molecules in the saliva of P. manillensis, but the substance that produces the paralyzing effect in P. manillensis is not known. In this...