Cardiovascular and metabolic effects of volemic expansion with hydroxyethyl starch 130/0,4 in domestic cats with induced hypovolemia/Efeitos cardiovascular e metabolico da reposicao volemica com hidroxietilamido 130/0,4 em felinos domesticos com hipovolemia induzida

• Published in: Ciência rural Vol. 39; no. 2; p. 428
• Main Authors: Soares, Andre Vasconcelos, Oleskovicz, Nilson, Nunes de Moraes, Aury, Flores, Fabiola Niederauer, Tamanho, Renato Batista, Pacheco, Acacio Duarte, Regalin, Doughlas, Carneiro, Ruiney, Armando, Aline Meireles
• Format: Journal Article
• Language: Portuguese
• Published: Universidade Federal de Santa Maria 01.03.2009
• ISSN: 0103-8478

The aim of this study was to compare the volemic expansion effects produced by hydroxyethyl starch 130/0.4 (HES 130/0.4) or blood, in female cats with induced hypovolemia. Twelve healthy adult female cats, crossbreed and weighing an average of 2.85 ± 0.28kg were used. They were induced into general anesthesia with isofluorane at 5V%, intubated and connected to a non-rebreathing system. After instrumentation, the animals were maintained under anesthesia with isofluorane at 1.3V% and maintained on pressure cycled mechanic ventilation. Afterwards, hypovolemia was induced by withdrawal of 30ml [kg.sup.-1] of blood from the femoral artery. After 60 minutes of stabilization of the patient, the treatments were initiated. In the hydroxyethyl starch group (GH, n=06) the animals received hydroxyethyl starch 130/0.4 as volemic expansion at the same volume of blood withdrawed, in the blood group (GS, n=06) the animals received their own withdrawed blood, being considered the control group. The systolic, diastolic and mean arterial pressures and central venous pressure increased after volemic expansion in both groups. An increase of PaC[O.sub.2] at T15, T30 and T60 in GH was observed. In addition, there was reduction of pH at T30 and T45 and [Na.sup.+] ions at T90 in GH. The arterial pressure restoration with the use of HES 130/0.4 was similar to the control group; the volemic expansion with HES 130/0,4 produces accentuated increase of CVP; the use of HES 130/0,4 in female cats submitted to hypovolemia did not produce clinically significant alterations in acid-base equilibrium. Key words: cats, hypovolemia, hidroxyethylstarch, blood. O objetivo deste estudo foi comparar os efeitos da expansao volemica produzida pelo hidroxietilamido 130/0,4 (HES 130/0,4) ou pelo sangue em gatas com hipovolemia induzida. Foram utilizadas 12 gatas adultas, sem raca definida (SRD), com peso medio de 2,85[+ ou -]0,28kg e higidas. Os animais foram induzidos a anestesia geral com isofluorano a 5V%, intubados e conectados a um sistema sem reinalacao de gases. Apos a instrumentacao, os animais foram mantidos sob anestesia com isoflurano em 1,3V% e mantidos em ventilacao mecanica, ciclada a pressao. Em seguida, foi induzida a hipovolemia por meio da retirada de 30ml [kg.sup.-1] de sangue da arteria femoral. Apos 60 minutos da estabilizacao do paciente, os tratamentos foram iniciados. No grupo hidroxietilamido (GH, n=06), os animais receberam, como reposicao volemica, o hidroxietilamido 130/0,4 no mesmo volume de sangue retirado e, no grupo sangue (GS, n=06), os animais receberam o proprio sangue retirado, sendo considerado grupo controle. A pressao arterial sistolica, a diastolica e a media e a pressao venosa central aumentaram apos a reposicao volemica em ambos os grupos. Observou-se, para o GH, aumento da PaC[O.sub.2] no T15, no T30 e no T60. Houve reducao do pH no T30 e no T45 e de ions [Na.sup.+] no T90 para GH. A restauracao das pressoes arteriais com a administracao de HES 130/0,4 foi similar ao grupo controle. A reposicao volemica com HES 130/0,4 produz aumento acentuado da PVC; e o uso do HES 130/0,4 em gatas submetidas a hipovolemia nao produziu alteracoes clinicamente significativas no equilibrio acido-basico. Palavras-chave: felino, hipovolemia, hidroxietilamido, sangue.