Human leukocyte antigen

• Published in: South African medical journal Vol. 109; no. 88; p. S30
• Main Authors: Meyer, P.W.A, Pepper, M.S, Agbedare, O, Gray, C.M, Mellet, J, Tshabalala, M
• Format: Journal Article
• Language: English
• Published: Health & Medical Publishing Group 01.08.2019
• Subjects: Africans; Antigens; B cells; Biodiversity; Genomes; Genomics; HLA antigens; Human genome; Immune response; Immunoglobulins; Major histocompatibility complex; Medical research; Peptides; Surgery; T cells; South Africa

The major histocompatibility complex, known as the human leukocyte antigen (HLA) complex in humans, forms an integral component of adaptive T cell immunity by presenting self and non-self peptides to the T cell receptor, thereby allowing clonal expansion of responding peptide-specific [CD4.sup.+] an...