Repulsive Axon Guidance by Draxin Is Mediated by Protein Kinase B (Akt), Glycogen Synthase Kinase-3[beta] (GSK-3[beta]) and Microtubule-Associated Protein 1B

• Published in: PloS one Vol. 10; no. 3
• Main Authors: Meli, Rajeshwari, Weisová, Petronela, Propst, Friedrich
• Format: Journal Article
• Language: English
• Published: Public Library of Science 16.03.2015
• Subjects: Chemotherapy; Colorectal cancer; Glycogen; Glycogen synthesis; Protein kinases

Draxin is an important axon guidance cue necessary for the formation of forebrain commissures including the corpus callosum, but the molecular details of draxin signaling are unknown. To unravel how draxin signals are propagated we used murine cortical neurons and genetic and pharmacological approac...