Evidence for the formation of a quinone methide during the oxidation of the insect cuticle sclerotizing precursor 1,2-dehydro-N-acetyldopamine

• Published in: The Journal of biological chemistry Vol. 267; no. 15
• Main Authors: Sugumaran, M. (University of Massachusetts at Boston, Boston, MA), Semensi, V, Kalyanaraman, B, Bruce, J.M, Land, E.J
• Format: Journal Article
• Language: English
• Published: 25.05.1992
• Subjects: DOPAMINA; DOPAMINE; INSECTA; QUINONAS; QUINONE; VIA BIOQUIMICA DEL METABOLISMO; VOIE BIOCHIMIQUE DU METABOLISME

1,2-Dehydro-N-acetyldopamine (dehydro-NADA) is an important catecholamine derivative involved in the cross-linking of insect cuticular components during sclerotization. Since sclerotization is a vital process for the survival of insects, and is closely related to melanogenesis, it is of interest to...