Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson’s disease

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 112; no. 28; pp. 8756 - 8761
• Main Authors: Kim, Chun-Hyung, Baek-Soo Han, Jisook Moon, Deog-Joong Kim, Joon Shin, Sreekanth Rajan, Quoc Toan Nguyen, Mijin Sohn, Won-Gon Kim, Minjoon Han, Inhye Jeong, Kyoung-Shim Kim, Eun-Hye Lee, Yupeng Tu, Jacqueline L. Naffin-Olivos, Chang-Hwan Park, Dagmar Ringe, Ho Sup Yoon, Gregory A. Petsko, Kwang-Soo Kim
• Format: Journal Article
• Language: English
• Published: National Academy of Sciences 2015
• Subjects: agonist; agonists; animal models; drug target; drugs; NR4A2; Nurr1; Parkinson disease; Parkinson's disease; therapeutics; transcription factors

Parkinson’s disease (PD), primarily caused by selective degeneration of midbrain dopamine (mDA) neurons, is the most prevalent movement disorder, affecting 1–2% of the global population over the age of 65. Currently available pharmacological treatments are largely symptomatic and lose their effi...