Intestinal and peritoneal mast cells differ in kinetics of quantal release

• Published in: Biochemical and biophysical research communications Vol. 469; no. 15; pp. 559 - 564
• Main Authors: Balseiro-Gomez, Santiago, M. Pilar Ramirez-Ponce, Jorge Acosta, Eva Ales, Juan A. Flores
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 2016
• Subjects: 5-HT; Amperometry; chondroitin sulfate; CTMC; exocytosis; functional properties; heparin; Ifoot; Imax; IMC; Mast cells; MMC; PMC; proteoglycans; Proteoglycans and serotonin; Qfoot; rats; Risem; secretion; secretory granules; serotonin; t1/2; tfoot

5-hydroxytriptamine (5-HT, serotonin) storage and release in mast cell (MC) secretory granules (SG) are dependent on serglycin proteoglycans (PG). This notion is based on the studies of MC of the connective tissue subtype that predominantly contain PG of the heparin type, whereas intestinal mucosal...