PDGFRα-positive cells in bone marrow are mobilized by high mobility group box 1 (HMGB1) to regenerate injured epithelia

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 108; no. 16; pp. 6609 - 6614
• Main Authors: Tamai, Katsuto, Yamazaki, Takehiko, Chino, Takenao, Ishii, Masaru, Otsuru, Satoru, Kikuchi, Yasushi, Iinuma, Shin, Saga, Kotaro, Nimura, Keisuke, Shimbo, Takashi, Umegaki, Noriko, Katayama, Ichiro, Miyazaki, Jun-ichi, Takeda, Junji, McGrath, John A, Uitto, Jouni, Kaneda, Yasufumi
• Format: Journal Article
• Language: English
• Published: National Academy of Sciences 2011
• Subjects: bone marrow; bone marrow cells; epithelial cells; epithelium; fluorescence; irradiation; medicine; mice; nucleoproteins; platelet-derived growth factor receptors; skin grafting; tissue repair

The role of bone marrow cells in repairing ectodermal tissue, such as skin epidermis, is not clear. To explore this process further, this study examined a particular form of cutaneous repair, skin grafting. Grafting of full thickness wild-type mouse skin onto mice that had received a green fluoresce...