p21CIP¹ attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 106; no. 45; pp. 19035 - 19039
• Main Authors: Liu, Manran, Casimiro, Mathew C, Wang, Chenguang, Shirley, L. Andrew, Jiao, Xuanmao, Katiyar, Sanjay, Ju, Xiaoming, Li, Zhiping, Yu, Zuoren, Zhou, Jie, Johnson, Michael, Fortina, Paolo, Hyslop, Terry, Windle, Jolene J, Pestell, Richard G
• Format: Journal Article
• Language: English
• Published: National Academy of Sciences 2009
• Subjects: breast neoplasms; carcinogenesis; cell culture; cell proliferation; cyclin-dependent kinase; epithelium; gene expression; humans; immunohistochemistry; mice; stem cells; therapeutics; transgenic animals

p21CIP¹/WAF¹ is a downstream effector of tumor suppressors and functions as a cyclin-dependent kinase inhibitor to block cellular proliferation. Breast tumors may derive from self-renewing tumor-initiating cells (BT-ICs), which contribute to tumor progression, recurrence, and therapy resistance. T...