Prion gene (PRNP) haplotype variation in United States goat breeds (Open Access publication)

• Published in: Genetics, selection, evolution Vol. 40; no. 5; pp. 553 - 561
• Main Authors: White, Stephen, Herrmann-Hoesing, Lynn, O'Rourke, Katherine, Waldron, Daniel, Rowe, Joan, Alverson, Janet
• Format: Publication
• Language: English
• Published: 2008
• Subjects: alleles; dairy breeds; genes; genetic variation; goat breeds; goats; haplotypes; prion diseases; prions; PRNP gene; scrapie; United States

Scrapie eradication efforts cost 18 million dollars annually in the United States and rely heavily upon PRNP genotyping of sheep. Genetic resistance might reduce goat scrapie and limit the risk of goats serving as a scrapie reservoir, so PRNP coding sequences were examined from 446 goats of 10 breed...