Nutritional and Physicochemical Characteristics of the Antidementia Acetylcho-linesterase-Inhibiting Methanol Extracts from Umbilicaria esculenta

To develop new antidementia nutraceuticals, a potent acetylcholinesterase (AChE)-inhibiting extract was screened from various extracts of nutritional mushrooms and lichens nutritional and its physicochemical properties were investigated. Among the several extracts tested, methanol extracts of Umbili...

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Bibliographic Details
Published inMycobiology Vol. 37; no. 3
Main Authors Lee, J.S., Paichai University, Daejeon, Republic of Korea, Min, G.H., Woosong University, Daejeon, Republic of Korea
Format Journal Article
LanguageEnglish
Published 01.09.2009
Subjects
ACETILCOLINESTERASA
ACETYLCHOLINESTERASE
Acetylcholinesterase inhibitor
Antidementia
Umbilicaria esculenta
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Summary:To develop new antidementia nutraceuticals, a potent acetylcholinesterase (AChE)-inhibiting extract was screened from various extracts of nutritional mushrooms and lichens nutritional and its physicochemical properties were investigated. Among the several extracts tested, methanol extracts of Umbilicaria esculenta fruiting body showed the highest AChE inhibitory activity of 22.4%. U. esculenta AChE inhibitor was maximally extracted when fruiting bodies were treated with 80% methanol at 40℃ for 18 h. The methanol extracts contained 18.9% crude lipid, 18.8% crude protein, and 11.6% total sugar. In addition, they contained 444 mg/g glutamic acid, 44 mg/g histidine, and 41 mg/g aspartic acid. The methanol extracts were soluble in a solution of methanol and 20% dimethylsulfoxide, insoluble in n-hexane, chloroform, and water, and were stable at 20~60℃ and pH 1.0~5.0 for 1 h.
Bibliography:2010003532
A50
ISSN:1229-8093
2092-9323