Agonistic action of thrombin and endothelin-1 on vascular and bronchomotor tone in pig

• Published in: Atti della Societa' Italiana delle Scienze Veterinarie (Italy) Vol. 56
• Main Authors: Ciminaghi, B, Albertini, M, Mazzola S, Clement, M.G. (Milan Univ. (Italy). Dipartimento di Patologia Animale, Igiene e Sanita Pubblica Veterinaria)
• Format: Conference Proceeding
• Language: Italian
• Published: 2002
• Subjects: BLOOD PRESSURE; BRONCHE; BRONCHI; BRONQUIOS; CERDO; ENZIMAS; ENZIMI; ENZYME; ENZYMES; EPITELIO; EPITHELIUM; FIBRAS MUSCULARES; FIBRE MUSCOLARI; FIBRE MUSCULAIRE; LUNGS; MUSCLE FIBRES; POLMONI; PORCIN; POUMON; PRESION SANGUINEA; PRESSION SANGUINE; PRESSIONE DEL SANGUE; PULMONES; SUINI; SWINE

To evaluate the role of thrombin and the involvement of endothelin-1 (ET-1) in regulation of bronchomotor and vascular tone, we used 18 anaesthetised, mechanically ventilated pigs, divided into three groups. Group 1 (n = 6) was treated with E. coli LPS (20 microng/kg/h for 180 min); group 2 (n = 6)...