Hypothalamic nitric oxide in hypoglycemia detection and counterregulation: a two-edged sword

• Main Authors: Fioramonti , Xavier (INRA , Dijon (France). UMR 1324 Centre des Sciences du Goût et de l'Alimentation ), Song , Zhentao (University of Medicine and Dentistry of New Jersey(US). Department of Physiology and Phamacology), Vazirani , Reema P. (University of Medicine and Dentistry of New Jersey(US). Department of Physiology and Phamacology), Beuve , Annie (University of Medicine and Dentistry of New Jersey(US). Department of Physiology and Phamacology), Routh , Vanessa H. (University of Medicine and Dentistry of New Jersey(US). Department of Physiology and Phamacology)
• Format: Publication
• Language: English
• Published: 2011
• Subjects: contre régulation; diabète; espèce active de l'oxygène; hypoglycémie; hypothalamus; monoxide d'azote

Hypoglycemia is the main complication for patients with type 1 diabetes mellitus receiving intensive insulin therapy. In addition to the obvious deleterious effects of acute hypoglycemia on brain function, recurrent episodes of hypoglycemia (RH) have an even more insidious effect. RH impairs the abi...