Transcriptomic and metabolomic profiling of chicken adipose tissue in response to insulin neutralization and fasting

• Published in: http://www.biomedcentral.com/bmcgenomics
• Main Authors: Ji , Bo (University of Tennessee, Knoxville(Etats-Unis). Department of Animal Science), Ernest , Ben (University of Tennessee, Knoxville(Etats-Unis). Department of Animal Science), Gooding , Jessica R. (University of Tennessee, Knoxville(Etats-Unis). Department of Chemistry), Das , Suchita (University of Tennessee, Knoxville(Etats-Unis). Department of Animal Science), Saxton , Arnold M. (University of Tennessee, Knoxville(Etats-Unis). Department of Animal Science), Simon , Jean (INRA , Nouzilly (France). UR 0083 Recherches Avicoles), Dupont , Joëlle (INRA , Nouzilly (France). UMR 0085 Physiologie de la Reproduction et des Comportements), Metayer-Coustard , Sonia (INRA , Nouzilly (France). UR 0083 Recherches Avicoles), Campagna , Shawn R. (University of Tennessee, Knoxville(Etats-Unis). Department of Chemistry), Voy , Brynn H.(auteur de correspondance)
• Format: Publication
• Language: English
• Published: 2012
• Subjects: adipogenesis; analyse statistique; arn; chiken adipose tissue; expression génique; fasting; fatty acid metabolism; glusose metabolism; insulin neutralization; insuline; microarray; métabolisme glucidique; poulet; spectrométrie de masse; tissu adipeux; transcriptome

BACKGROUND: Domestic broiler chickens rapidly accumulate adipose tissue due to intensive genetic selection for rapid growth and are naturally hyperglycemic and insulin resistant, making them an attractive addition to the suite of rodent models used for studies of obesity and type 2 diabetes in human...