Microtubules do not promote mitotic slippage when the spindle assembly checkpoint cannot be satisfied

• Main Authors: Brito, Daniela A, Yang, Zhenye, Rieder, Conly L
• Format: Journal Article
• Language: English
• Published: Rockefeller University Press 18.08.2008

When the spindle assembly checkpoint (SAC) cannot be satisfied, cells exit mitosis via mitotic slippage. In microtubule (MT) poisons, slippage requires cyclin B proteolysis, and it appears to be accelerated in drug concentrations that allow some MT assembly. To determine if MTs accelerate slippage,...